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HTA Consulting for EU market access, pricing and reimbursement

HTA consulting is becoming a critical part of market access strategy for pharmaceutical, biotech and MedTech companies operating in Europe. Under the new EU Health Technology Assessment Regulation (HTAR), Regulation (EU) 2021/2282, innovative therapies are now subject to a centralised Joint Clinical Assessment (JCA) process involving all EU Member States. This new framework significantly changes how companies prepare clinical evidence, demonstrate comparative effectiveness and plan reimbursement and pricing activities across European markets.

For companies, this creates a significantly more demanding HTA environment. Preparing a JCA dossier requires advanced statistical analyses, indirect treatment comparisons, evidence synthesis and detailed comparisons against existing standards of care, all within strict regulatory timelines. At the same time, organisations must align clinical, regulatory and market access strategies much earlier in development than before.

Billev Pharma East provides strategic and operational HTA consultancy support throughout both the EU and national HTA process. We help clients prepare JCA documentation and clinical evidence packages for EU-level assessments, while also supporting national HTA procedures related to pricing, reimbursement and market access. This includes pharmacoeconomic analyses, budget impact models, reimbursement strategy and adaptation of global evidence to local market requirements.

How to Reach us?

Billev farmacija vzhod, d. o. o.
Billev Pharma East Ltd.
Tržaška cesta 202

1000 Ljubljana

Slovenia

Billev Pharma East HTA Consulting and HTA Consultancy Services

Billev Pharma East provides strategic and operational HTA consulting support throughout both the EU-level Joint Clinical Assessment (JCA) process and national HTA procedures. We work with pharmaceutical, biotech and MedTech companies that need support with evidence generation, clinical evaluation, reimbursement strategy and market access planning under the new EU HTA framework.

In the EU phase of HTA, we support companies with the preparation of JCA documentation and clinical evidence packages required under Regulation (EU) 2021/2282. This includes comparative clinical evidence assessment, indirect treatment comparisons, statistical analyses, evidence synthesis and support with PICO requirements. Because JCA timelines are highly demanding and run in parallel with EMA procedures, companies increasingly need specialised HTA consultancy support early in development.

Beyond the EU-level clinical assessment, we also support national HTA procedures where individual Member States evaluate pricing, reimbursement and market access conditions. While the JCA focuses on relative clinical effectiveness and safety, economic evaluation and reimbursement decisions remain under national competence.

Our HTA consultancy services therefore also include pharmacoeconomic analyses, budget impact modelling, reimbursement dossier preparation and adaptation of global evidence to local payer requirements. We help companies demonstrate the value of their products within national healthcare systems and support strategic market access planning across Slovenia and other European markets. Learn more about our pricing and reimbursement services.

As a specialised pharmaceutical consultanc, Billev Pharma East combines expertise in regulatory affairs, medical consultancy, pharmacovigilance and market access to support clients throughout the full product lifecycle. Our team works closely with EU competent authorities and international pharmaceutical companies to deliver tailored solutions aligned with evolving European HTA requirements.

Joint Clinical Assessment (JCA) Support

Billev Pharma East supports pharmaceutical, biotech and MedTech companies with the preparation of Joint Clinical Assessment (JCA) documentation required under the EU HTA Regulation (Regulation (EU) 2021/2282). The JCA process requires comprehensive comparative clinical evidence demonstrating the relative effectiveness and safety of new health technologies compared with existing standards of care across EU Member States.

Our HTA consulting services include support with clinical evidence strategy, indirect treatment comparisons, statistical analyses, evidence synthesis, PICO requirements and preparation of JCA submission dossiers. We help companies align evidence generation with both EU-level assessment requirements and future national reimbursement expectations to support successful market access across Europe.

Why HTA Consulting Matters for Market Access and Reimbursement

Under the new EU HTA framework, obtaining marketing authorisation is no longer sufficient to secure successful commercialisation across Europe. Companies must now demonstrate not only the clinical value of their product through the Joint Clinical Assessment (JCA), but also its economic value at national level, where pricing, reimbursement and market access decisions remain under the responsibility of individual Member States.

This creates a much more complex environment for pharmaceutical and MedTech companies. While the EU-level HTA process introduces a harmonised clinical assessment, national authorities continue to apply their own reimbursement criteria, healthcare priorities and payer expectations. As a result, companies must prepare evidence that supports both centralised EU assessment requirements and country-specific market access strategies simultaneously.

Effective HTA consulting therefore becomes critical much earlier in product development. Companies increasingly need integrated clinical, regulatory and pharmacoeconomic planning to avoid delays in reimbursement decisions and patient access. This is especially important for innovative therapies, oncology products, orphan drugs and advanced therapies entering the EU market under the new HTAR timelines.

At Billev Pharma East, we help clients navigate both the EU and national dimensions of HTA by aligning clinical evidence generation, reimbursement strategy and pharmacoeconomic evaluation into a single market access approach tailored to European requirements.

Prepare for the New EU HTA Environment

The implementation of the EU HTA Regulation is transforming how companies approach clinical evidence, reimbursement and market access across Europe. Organisations that begin preparing early for Joint Clinical Assessments (JCA) and national HTA requirements will be better positioned to accelerate reimbursement timelines and support successful product launches.

Billev Pharma East provides specialised HTA consulting and HTA consultancy services tailored to pharmaceutical, biotech and MedTech companies navigating the evolving European market access landscape. From JCA preparation and evidence strategy to pharmacoeconomic evaluation and reimbursement support, we help clients align clinical, regulatory and commercial objectives within the new HTA framework.

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