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Toxicology Consultancy

Toxicology Consultancy for Pharmaceuticals & Medical Devices

Toxicology consultancy support is becoming increasingly important for pharmaceutical and medical device companies as toxicological and regulatory requirements continue to evolve. Companies developing new products are expected to establish a clear preclinical strategy, assess risks associated with impurities and nitrosamines, evaluate biological safety, and prepare scientifically justified documentation for regulatory submissions. As a result, many companies rely on experienced toxicology consultants and specialized toxicology consulting services to support efficient development and compliance with EMA, FDA, ICH, and ISO expectations.

In practice, development teams often face challenges translating complex regulatory requirements into efficient development strategies. Toxicological gaps identified late in development can lead to additional authority questions, delayed clinical timelines, increased costs, or setbacks during registration.

A structured toxicology consultancy approach helps companies support safer product development, minimize regulatory risk, and prepare toxicological documentation aligned with current global expectations.

How to Reach us?

Billev farmacija vzhod, d. o. o.
Billev Pharma East Ltd.
Tržaška cesta 202

1000 Ljubljana

Slovenia

How Billev Pharma East toxicology consultancy can help you

Billev Pharma East provides toxicology consultancy support for pharmaceutical, biotechnology, and medical device companies that need scientifically robust and regulator-ready toxicological strategies throughout product development and registration activities.

We help clients plan and execute preclinical development programs for new medicinal products, supporting the definition of nonclinical strategies, toxicology planning, study coordination, and preparation for regulatory interactions.

Our toxicology consultants also perform toxicological assessment of impurities and nitrosamines, including scientific risk evaluation, toxicological justification, and preparation of documentation aligned with current EMA, FDA, and ICH expectations. Nitrosamine assessment and impurity qualification have become critical regulatory requirements across pharmaceutical development and lifecycle management activities.

For medical device manufacturers, our toxicology consultancy supports biological safety and biocompatibility evaluation activities in accordance with ISO 10993 requirements. This includes toxicological risk assessment, extractables and leachables evaluation, and preparation of toxicological documentation supporting MDR submissions and biological evaluation programs.

We also prepare preclinical and toxicological documentation required for pharmaceutical and medical device registration, including toxicological expert reports, nonclinical overviews, IMPD and IND toxicology sections, biological evaluation documentation, and other regulatory submission materials designed to support efficient communication with regulatory authorities and notified bodies.

Why Toxicology Consultancy is critical for regulatory approval

Toxicological assessment is no longer viewed as a standalone regulatory requirement performed late in development. Regulatory authorities increasingly expect companies to establish a proactive toxicology strategy early in product development in order to identify potential safety risks, support clinical progression, and avoid delays during submission review.

For pharmaceutical companies, this includes appropriate evaluation of impurities, nitrosamines, extractables and leachables, and nonclinical safety data required for IND, CTA, NDA, EU MAA, and other global submissions. Medical device manufacturers are also facing increasing scrutiny related to biological safety, toxicological risk assessment, and ISO 10993 compliance within MDR submissions. Regulatory expectations continue to evolve across both industries, particularly regarding scientific justification and documentation quality.

Working with an experienced toxicology consultant helps companies build a scientifically sound and regulator-ready strategy from the early stages of development. This reduces the risk of unexpected toxicological gaps, additional authority questions, delayed timelines, and costly redevelopment activities later in the process. Toxicology consultancy support is increasingly used not only for regulatory compliance, but also to support more efficient development planning and faster progression toward approval.

Partner With an Experienced Toxicology Consultancy

Successful product development and regulatory approval increasingly depend on a well-structured toxicological strategy supported by scientifically robust documentation and regulatory expertise. Working with an experienced toxicology consultant helps companies reduce regulatory uncertainty, address complex safety requirements, and prepare submission packages aligned with current global expectations.

Billev Pharma East supports pharmaceutical, biotechnology, and medical device companies with practical and regulatory-focused toxicology consultancy services designed to support efficient development and successful registration activities across global markets.

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